Curing Werewolf - The Elder Scrolls V: Skyrim wiki

At the end of the Companions Questline, a Radiant Quest: Purity becomes available for those adventurers who wish to rid themselves of the beast within. As a part or that quest you must cut off the head of a Glenmoril Witch, bringing it into the depths of the Tomb of Ysmgramor, draw the spirit of the wolf from your body, and defeat it. Once the ritual is complete, your cure is permanent, and you cannot contract Lycanthropy again.

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