Ms. 'Splosion Man is a sequel to the popular 2009 XBLA game 'Splosion Man. After succeeding in finally capturing the crazed 'Splosion Man using an electrified cake to lure him into an "unsplodeable" capsule, the Big Science staff engages in an afterparty whose booze-fuelled antics lead to the accidental creation of a new 'Splosion creature. This more effeminate abomination, appropriately dubbed Ms. 'Splosion Man, starts out on her own rampage through the Big Science laboratories. The game is priced at 800 Microsoft Points.
The title, and concept of a female protagonist identical to the previous male protagonist, pays homage to Ms. Pac-Man.