600 XP, Cash
Talk to Omar Torres who is in bungalow #17 near the pools southwest of the Lifeguard Tower. The location you need will be marked on your mini-map. Once you find the trail of blood, follow it to a downstairs bathroom. The Thug has the key so you must kill him to get it.
Once you get back to Omar, you can get into the next room. The safe is behind the turtle painting. Talk to Omar again to get your reward. Talk to Omar again to start the Omar Escort side quest.